Inflammatory Bowel Disease

Discussing the latest advances in Crohn’s disease and ulcerative colitis

Effectiveness of Early Drug Therapy in Children with Crohn’s Disease

Posted on April 17th, 2014 by Margaret Shepard

Michael Stephens, M. D., discusses a recent article published in Gastroenterology about the effectiveness of early drug therapy in children with Crohn's disease.

The research project is part of a larger project initiated by PROKIIDS. This research project looks at 1,800 children, 1,200 with Crohn's disease. All of the patients are being followed from the time they are diagnosed with Crohn's disease through the years moving forward. The goal of the study is to identify markers that might predict which patients will have a severe case of Crohn's disease.

The current research study looks at outcomes and compares three different types of treatments. The first group receives anti-TNF therapy. The second group received immune modulating therapy. The [...]

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The Kirsteins’ Story

Posted on April 9th, 2014 by Margaret Shepard

Previously posted on Sharing Mayo Clinic.

Sam and Laura Kirstein first met in college where they both were runners on the school's athletic teams. They had one other thing in common: both had been diagnosed with inflammatory bowel disease (IBD). Sam had ulcerative colitis; Laura had Crohn's disease. And for both, IBD soon halted their active lifestyles.

As their symptoms worsened, Sam and Laura feared that their athletic careers were over. "There were a number of years where I really didn't do anything," says Laura. "It's difficult enough to manage a regular life with IBD, let alone trying to throw in athletics." Laura eventually found the right mix of medications to keep her symptoms in check. Medications didn't work for [...]

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Gut Bacteria and Early Pediatric Crohn’s Disease

Posted on April 3rd, 2014 by Margaret Shepard

Michael Stephens, M. D., discusses a recent study published in Cell Host Microbe about pediatric Crohn's disease. The study looks at the microbiome in children with Crohn's disease compared to healthy children.

Researchers and doctors believe there is a dysfunctional interface with the types of bacteria and other organisms colonizing in the gut of children with Crohn's disease. There were almost 700 patients involved in this study and 400 of them had Crohn's disease. The samples from the patients were collected right at diagnosis so there weren't any changes that needed to be explained due to the treatment patients were receiving for their Crohn's disease.

The researchers found very different types of families of bacteria in the [...]

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Crohn’s Disease Strictures

Posted on March 26th, 2014 by Margaret Shepard

David Bruining, M. D., discusses a recent study published in the Inflammatory Bowel Diseases journal about Crohn's disease strictures. The study results highlight a move toward noninvasive or non-surgical approaches for Crohn's disease patients.

Crohn's disease initially begins as an inflammatory process. For many patients, it grows to be fibrostenotic disease manifesting in strictures. Endoscopic dilatation of Crohn's disease is an important topic because a third of Crohn's disease patients will develop strictures from surgery over ten years. Eighty percent of Crohn's disease patients will have surgery over a lifetime.

This study, completed by four academic institutes in the United Kingdom, looked at 79 patients with Crohn's disease related strictures. The results showed that endoscopic dilatation was [...]

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Targeting Treatment for Ulcerative Colitis Patients

Posted on March 20th, 2014 by Margaret Shepard

Sunanda Kane, M. D., discusses a recent study published in the Inflammatory Bowel Diseases journal about the feasibility of endoscopic assessment and targeting treatment for ulcerative colitis patients.

Patients with ulcerative colitis usually end up on medications like Humira or Remicade and wonder if the medications are doing any good. Researchers at the University of California at San Diego followed patients who were on either Humira of Remicade for a period of a year. The researchers were able to show that the colon can heal with repeated endoscopic tests and adjustments of medications.

If you have ulcerative colitis and are on either Humira or Remicade and feeling better, that's good news. The next step is to make [...]

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Diffusion-Weighted MRI

Posted on March 14th, 2014 by Margaret Shepard

David Bruining, M. D., discusses a recent study published in the American Journal of Gastroenterology about diffusion-weighted magnetic resonance imaging in inflammatory bowel disease. Diffusion-weighted imaging (DWI) is a new method of assessing the small bowel in patients with Crohn's disease.

What's unique about this study is researchers from France looked at 130 patients with Crohn's disease. The researchers performed routine MRIs but also looked at additional images with DWI. This type of imaging looks at the properties of water molecule transfer. In inflamed tissue, this transfer could be impaired and the abnormal segments in the small bowel could be identified. In the 130 patients with Crohn's disease, standard MRI images scores were compared with DWI scores. The results showed [...]

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IBD and Hepatitis A

Posted on March 12th, 2014 by Margaret Shepard

Doctors are starting to learn which vaccines patients with IBD may have lost response and protection to and which vaccines patients with IBD need a booster shot for. Jeanne Tung, M.D., discusses a recent study published in the Inflammatory Bowel Diseases Journal focusing on the hepatitis A vaccine and inflammatory bowel diseases. Hepatitis A is a virus passed through contaminated food or water supply and can cause severe vomiting, diarrhea, and liver inflammation.  

The study, conducted in Korea, gave 491 patients two shots of the hepatitis A vaccine and measured how much of the hepatitis A vaccine was still in their body.  At the end of the study, the results showed patients had a good response rate [...]

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Technology and IBD

Posted on March 7th, 2014 by Margaret Shepard

Jeanne Tung, M. D., discusses advancements in technology and how it helps to treat patients with inflammatory bowel diseases.

A group of pediatric gastroenterologists are using an iPad application to track patients' symptoms. This app tries to enhance the communication between the doctor and the patient. The patients get an automated response when to take their medication and also tries to track their symptoms if there are side effects to the medication, stress triggers, or food triggers. This app feeds the information back to the doctor's office to help make the best decisions for the patient.

The Oklahoma Medical Center and the Mayo Clinic are working on a iPad quiz game app. When patients visit the doctor's office, [...]

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