Inflammatory Bowel Disease

Discussing the latest advances in Crohn’s disease and ulcerative colitis

December 18th, 2014 · Leave a Comment

Vedolizumab Is Better for Ulcerative Colitis Than Crohn's Disease

By Margaret Shepard

In December 2013, two Food and Drug Administration (FDA) advisory committees voted in favor of recommending vedolizumab for treatment of both types of inflammatory bowel disease.

A theoretical concern about vedolizumab is the risk of progressive multifocal leukoencephalopathy (PML), a potentially fatal brain infection associated with vedolizumab's parent molecule, natalizumab (Tysabri), which is approved for use in both multiple sclerosis and CD.

Edward V. Loftus Jr., M.D., a gastroenterologist at Mayo Clinic in Minnesota, points out that natalizumab affects adhesion molecules at the level of the blood-brain barrier system as well as in the gut. "The goal has always been to develop more gut-specific targets," he says.

Read more about vedolizumab in the Digestive Diseases update.

To learn more about IBD, visit mayoclinic.org/ibd.

Tags: clinical trials, Crohn's disease, Edward Loftus, IBD, ulcerative colitis, Vedolizumab

December 12th, 2014 · Leave a Comment

Small Bowel Imaging and Crohn's Disease

By Margaret Shepard

Advances in small bowel imaging over the past decade have transformed the diagnosis and management of inflammatory bowel disease. New modalities such as CT and MR enterography, CT and MR enteroclysis, capsule endoscopy (CE), and balloon-assisted endoscopy (BAE) have become essential for evaluating the extent and severity of Crohn's disease (CD) and monitoring intestinal response to treatment.

Read more about the advances in imaging the Digestive Diseases update.

For more information about inflammatory bowel disease, visit mayoclinic.org/IBD.

 

Tags: Crohn's disease, IBD, small bowel imaging

December 5th, 2014 · Leave a Comment

IBD Biobank

By Margaret Shepard

In 2013, Mayo Clinic instituted an inflammatory bowel disease (IBD) serum biobank involving Mayo campuses in Arizona, Florida and Minnesota and the Mayo Clinic Health System. The goal was to use serologic samples from patients with diagnosed ulcerative colitis (UC) or Crohn's disease (CD) to advance biomarker research that might one day improve diagnosis, prognosis and treatment of IBD.

A year after its inception, a serum biobank that unites research across Mayo Clinic is helping identify new serologic biomarkers in patients with Crohn's disease and advancing other IBD research. Read more about the biobank here.

For more information on IBD, visit mayoclinic.org/ibd.

Tags: biobank, Crohn's disease, IBD, ulcerative colitis

November 24th, 2014 · Leave a Comment

The Natural History of Crohn's Disease and Ulcerative Colitis in Olmsted County

By Margaret Shepard

Edward Loftus Jr., M.D., discusses the the epidemiology and natural history of Crohn's disease and ulcerative colitis in Olmsted County during Grand Rounds presented by the Center for Clinical and Translational Science. Watch the video on the Medical Professionals Video Center.

For more information about IBD, visit mayoclinic.org/ibd.

Dr. Loftus is a gastroenterologist at Mayo Clinic.

Tags: Crohn's disease, Edward Loftus, Grand Rounds, ulcerative colitis

November 19th, 2014 · Leave a Comment

Diet and Inflammatory Bowel Disease

By Margaret Shepard

Edward Loftus Jr., M.D., a gastroenterologist at Mayo Clinic, discusses the topic of using nutrition in the setting of inflammatory bowel disease (IBD), dietary changes that may help patients with IBD, and the difficulty of proving whether or not specific diets are helpful in treating IBD.

 

For more information about IBD, visit mayoclinic.org/ibd.

Tags: diet, dietary changes, Edward Loftus, IBD, Nutrition

November 14th, 2014 · Leave a Comment

IBD and Cervical Abnormalities

By Margaret Shepard

Sunanda Kane, M.D., discusses a recently published study in Clinical Gastroenterology and Hepatology about cervical abnormalities in women with inflammatory bowel disease.

Data in the past has suggested women with IBD have an increased risk for cervical abnormalities found on pap smears. This is due to the immunosuppressants used to treat patients with Crohn's disease and ulcerative colitis.

A new study just published compares a large group of women with IBD to women without IBD. The study shows women with IBD have just as much screening as women without IBD. The risk for cervical abnormalities was higher in women with IBD. In women with Crohn's disease, there was an increased risk for cervical cancer development, about 50% higher than the healthy population.

What does this mean for women with IBD? It means women should get annual pap smears and any abnormal cells identified should be looked into further.

Read the full article online here.

For more information about IBD, visit mayoclinic.org/ibd.

Dr. Kane is a gastroenterologist at Mayo Clinic.

Tags: cervical abnormalities, IBD, Sunanda Kane

November 7th, 2014 · Leave a Comment

Management of IBD in Pregnancy

By Margaret Shepard

Sunanda Kane, M.D., discusses the management of inflammatory bowel disease and pregnancy during Grand Rounds. She provides an update about recent research in IBD and pregnancy. Watch the video on the Medical Professionals Video Center.

For more information about IBD, visit mayoclinic.org/ibd.

Dr. Kane is a gastroenterologist at Mayo Clinic.

Tags: Grand Rounds, IBD, Pregnancy, Sunanda Kane

October 31st, 2014 · Leave a Comment

Patient Story: Scott Hennen on Ulcerative Colitis and Mayo Clinic

By Margaret Shepard

Story originally posted on Sharing Mayo Clinic.

Scott Hennen, a radio talk show host from Fargo, ND, had surgery at Mayo Clinic to remove his colon, which had developed several sites with precancerous cells related to his ulcerative colitis, which was first diagnosed in 1997.

Scott had previously described his reasons for being public about his medical condition in this post. In the video below, he offers more background on his medical history and why he came to Mayo Clinic for his operation:

For more information about IBD, visit mayoclinic.org/IBD.

Tags: patient story, Sharing Mayo Clinic, ulcerative colitis

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