Inflammatory Bowel Disease

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March 12, 2014

IBD and Hepatitis A

By Margaret Shepard, Communications Specialist

Doctors are starting to learn which vaccines patients with IBD may have lost response and protection to and which vaccines patients with IBD need a booster shot for. Jeanne Tung, M.D., discusses a recent study published in the Inflammatory Bowel Diseases Journal focusing on the hepatitis A vaccine and inflammatory bowel diseases. Hepatitis A is a virus passed through contaminated food or water supply and can cause severe vomiting, diarrhea, and liver inflammation.  

The study, conducted in Korea, gave 491 patients two shots of the hepatitis A vaccine and measured how much of the hepatitis A vaccine was still in their body.  At the end of the study, the results showed patients had a good response rate of 92-99%. The results did find that patients taking anti-TNF drugs, such as Remicade or Humira, had lower response rates than patients taking other medications. The response rate for patients taking anti-TNF drugs was 92%.

This study shows that patients with IBD who get the hepatitis A vaccine will generally be very well protected. It may be a good idea to get the hepatitis A vaccine before going on an anti-TNF drug.

To read the full article, click here.

For more information on IBD, visit

Dr. Tung is a pediatric gastroenterologist at Mayo Clinic.

Tags: Hepatitis A, IBD, Inflammatory Bowel Disease Journal, Jeanne Tung, Study Findings, vaccines

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