Inflammatory Bowel Disease

Discussing the latest advances in Crohn’s disease and ulcerative colitis

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Oct 15, 2018 · Exclusive Enteral Nutrition and Pediatric Crohn’s Disease

So, I get what EEN is, what it does, what it helps us avoid (steroids and their side effects) but what I don't understand is what mechanism are we targeting with this treatment? Why THIS treatment exactly or why Pediasure or similar formula?
Like are we trying to remove any inflammatory substances? Are we trying to starve out certain types of gut bacteria and which ingredients do that? Are we trying to feed certain types of gut bacteria and what ingredients do that? Are we trying to overcome what may have been poor nutrition by the patient? Is it a matter of giving the gut a rest from regular food by only feeding overnight? Are we trying to induce gene expression of certain alleles in the patient that will improve conditions and which ingredients do that? Are we trying to induce gene expression in the gut bacteria to improve the conditions and which ingredients do that? I mean, what exactly are we targeting with something like ensure or boost or Nestle, etc?

Because to me, when one looks at the ingredients in most of these, some of them make sense, but some of them don't (carageenan, corn oil). The literature reads like "Hey we tried giving people this nutrient rich syrup, and it worked like 70-80% of the time" but there's no explanation as to what mechanisms this specific cocktail is targeting and why.

Is that information somewhere? I can see the efficacy in the stats, I can see they recorded a lot of helpful biomarkers as part of the study, but I just can't see what thought was put into the ingredients list. Because if its just a matter of putting the right ingredients into the shake, then one would imagine we could skip the shake salesman and put the right ingredients directly into our meals. Any thoughts before I put my child on this regimen?

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