Women with inflammatory bowel disease (IBD) are at increased risk for adverse birth outcomes such as preterm delivery and small for gestational age (SGA) infants, and most recognized cases have underlying placental causes. Dr. Sunanda Kane, M.D., discusses a study, published in Annals of Gastroenterology that examined whether women with IBD have a higher rate of placental inflammation than non-IBD controls.
Researchers compared placental tissue of 26 women who had Crohn's disease or ulcerative colitis, and had delivered healthy children, with the placental tissue of 26 women who gave birth around the same time but didn't have IBD. They found that despite having an autoimmune inflammatory condition, the placenta did not appear to be at any increased risk of inflammation in the group of women who suffered from IBD.
While this is reassuring data, Dr. Kane explains that it does not change the recommendation for continuing anti-inflammatory drugs during pregnancy in women with IBD. Understanding what affects poor birth outcomes in IBD women is crucial to develop efficient and targeted therapeutics to improve births.
Read the full study online here.
For more information about IBD, visit mayoclinic.org/IBD.
Dr. Kane is a gastroenterologist at Mayo Clinic.